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Figure 1 | Particle and Fibre Toxicology

Figure 1

From: Nanometer-long Ge-imogolite nanotubes cause sustained lung inflammation and fibrosis in rats

Figure 1

Ge-imogolites induce a strong inflammation in rat lungs 3 d after intra-tracheal instillation. Wistar rats were intra-tracheally instilled with NaCl (controls), 2 mg crocidolite, 0.02 to 2 mg SW and DW Ge-imogolites. Inflammation was investigated in the BAL after 3 d. (A) LDH activity and (B) total proteins measured in BALF. BAL number of (C) total cells, (D) macrophages, (E) neutrophils and (F) lymphocytes. *P < 0.05, **P < 0.01 and ***P < 0.001 relative to NaCl-treated rats (Dunnett multiple comparisons test between NaCl and Ge-imogolite-treated rats or t-test between NaCl and crocidolite-treated rats, n = 3–6, means ± SEM).

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