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Table 1 Energy metabolism response to intracerebroventricular infusion of infliximab in KKay mice exposed to PM 2.5

From: Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes

Phase

Measured index

Method

FA-CON vs PM-CON

PM-CON vs PM-Inflix

Estimate

SE

p-value

Estimate

SE

p-value

Light + Dark

O2

Avg

−193.125

170.601

0.270

−182.738

170.601

0.296

  

RM

−171.714

66.509

0.010

−184.556

66.509

0.006

 

CO2

Avg

−186.684

197.569

0.355

−248.623

197.569

0.222

  

RM

−159.923

79.478

0.044

−248.577

79.478

0.002

 

RER

Avg

−0.001

0.015

0.969

−0.025

0.015

0.113

  

RM

0.001

0.008

0.899

−0.025

0.008

0.003

 

Heat

Avg

−0.020

0.033

0.548

−0.076

0.033

0.030

  

RM

−0.016

0.012

0.204

−0.078

0.012

0.000

Dark

O2

Avg

−272.695

195.576

0.178

−186.257

195.576

0.352

  

RM

−278.074

85.804

0.001

−186.729

85.804

0.030

 

CO2

Avg

−273.400

234.828

0.257

−289.425

234.828

0.231

  

RM

−280.245

106.432

0.009

−287.488

106.432

0.007

 

RER

Avg

−0.002

0.019

0.901

−0.037

0.019

0.062

  

RM

−0.003

0.010

0.753

−0.036

0.010

0.000

 

Heat

Avg

−0.035

0.035

0.338

−0.079

0.035

0.036

  

RM

−0.036

0.016

0.022

−0.079

0.016

0.000

  1. O2 consumption, CO2 production, RER and heat production of mice measured by indirect calorimetry over a 24 hrs period (from 10:00 am to 10:00 am the next day) after 5-week PM2.5 exposure. n = 6.
  2. Avg = analysis performed based on mice averages over cycles. Covariates in the model include PM exposure, treatment group, and the interaction between PM and treatment group.
  3. RM = analysis with repeated measurements. The correlation structure within mice was assumed to be autoregressive-1. Covariates in the model include PM, treatment group, PM x treatment interaction, and time.
  4. Mean model using averages over cycles (Avg): E (Y) = b0 + b1PM + b2 Trt + b3 PM*Trt.
  5. Mean model using repeated measures data (RM): E (Y + b1P) = b0 M + b2 Trt + b3 PM*Trt + b4cycle.
  6. Covariance structure: autoregressive-1.