Nitric oxide and superoxide mediate diesel particle effects in cytokine-treated mice and murine lung epithelial cells — implications for susceptibility to traffic-related air pollution

Table 3 BAL fluid indices and lung glutathione in mice 48 h after saline- or cytokine-treatment

	Saline	Cytomix
	*n =* 4	n = 4
BAL fluid cells per lung (x10 ³ )
Total Cells	88.7 ± 4.8	264 ± 25.5*
Macrophages	72.5 ± 9.5	101 ± 7.1
Neutrophils	14.7 ± 6.7	119 ± 13.1*
Lymphocytes	1.4 ± 0.7	57.1 ± 16.7*
BAL fluid biochemistries
LDH (U/mL)	37.5 ± 9.1	55.3 ± 13.7
Total Protein (μg/mL)	67.6 ± 5.2	126.6 ± 21.4
Albumin (μg/mL)	15.2 ± 1.9	24.6 ± 2.5*
Lung glutathione (nmol/g tissue)
GSH	4050 ± 484	4908 ± 1080
GSSG	331 ± 12.5	305 ± 74.1
GSH:GSSG ratios	12.3 ± 1.6	16.1 ± 3.5

Data are expressed as means (± SEM). Asterisk (*) indicates significantly different than saline-exposed mice ( p < 0.05).

ISSN: 1743-8977