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Figure 5 | Particle and Fibre Toxicology

Figure 5

From: Nitric oxide and superoxide mediate diesel particle effects in cytokine-treated mice and murine lung epithelial cells — implications for susceptibility to traffic-related air pollution

Figure 5

ROS changes and cell injury in cytomix + DEP-exposed LA-4 cells. (A) ROS production, measured by the fluorescence of H2DCFDA oxidation, in cytomix + DEP-exposed (25 μg/cm2 × 2 h) LA-4 cells, with or without SOD (200 U/mL) or 1400W (100 μM) treatment. Data are expressed as mean fold-increase (± SEM) over control cells and is representative of three independent experiments. Significance ( p < 0.05) indicated by: * vs. control; ** vs. cytomix + DEP. (B) Cytotoxicity of cytomix + DEP- exposed cells (25 μg/cm2; x 24 h) in the presence of FeTMPyP (10 μM). Data are expressed as mean fold increase (± SEM) of LDH release over control cells and is representative of three independent experiments. Significance ( p < 0.05) indicated by: * vs. control; ** vs. cytomix + DEP.

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