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Figure 7 | Particle and Fibre Toxicology

Figure 7

From: Use of back-scatter electron signals to visualise cell/nanowires interactions in vitro and in vivo; frustrated phagocytosis of long fibres in macrophages and compartmentalisation in mesothelial cells in vivo

Figure 7

Images of the parietal pleura surface 24 hour post pleural instillation of AgNW 5 and AgNW 10 . Overview of the lesion area on the surface of the parietal pleura with AgNW5 (A) and AgNW10 (C). The yellow arrow indicates a nanowire which is not taken up by inflammatory cells whereas the star indicates a fibre that is fully phagocytosed but can be visualised underneath the surface of the cell. The white arrow indicates nanowires which are protruding out of cells. B) This figure shows AgNW5 that are fully phagocytosed by pleural macrophages but can be visualised underneath the surface as indicated by the star. D) AgNW10 is causing frustrated phagocytosis in a macrophage in the centre of the image. The unclosed cell membrane is indicated by the black arrows and exposed fibre surface is indicated by the white arrow. The cross on the lower right of the image indicates fibres which are largely internalised but whose tips rise vertically to penetrate the cell surface adjacent to the other long fibre.

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