Skip to main content
Figure 10 | Particle and Fibre Toxicology

Figure 10

From: Use of back-scatter electron signals to visualise cell/nanowires interactions in vitro and in vivo; frustrated phagocytosis of long fibres in macrophages and compartmentalisation in mesothelial cells in vivo

Figure 10

Length categories of frustrated phagocytosis and pleural inflammation and diagrammatic representation of frustrated phagocytosis. A) Summary of frustrated phagocytosis and pleural inflammation in vitro and in vivo. B) Diagrammatic representations of the length-dependent effects seen at the level of the macrophage in granulomas on the parietal pleura after instillation of fibres. These suggest that fibres 3 μm and shorter can be phagocytosed with no inflammation and cleared from the pleural space. Fibres 5 μm long can be entirely enclosed but are associated with inflammation whilst 10 μm fibres clearly cause frustrated phagocytosis and inflammation.

Back to article page