Table 1 Summary of ESTR mutation rates in F2 offspring of prenatally exposed female C57BL/6 mice
From: NanoTIO2 (UV-Titan) does not induce ESTR mutations in the germline of prenatally exposed female mice
Group | probe | N (F2 offspring) | Mutant bands | Mutation rate ± SEM (P valuea) | ||
|---|---|---|---|---|---|---|
Paternal | Maternal | Paternal | Maternal | |||
origin | origin | origin | origin | |||
Female controls | Ms6-hm | 164 | 11 | 5 | 0.0671 ± 0.0002 | 0.0305 ± 0.0002 |
Female controls | Hm-2 | 164 | 9 | 7 | 0.0549 ± 0.0004 | 0.0427 ± 0.0004 |
Female controls | Total | 164 | 20 | 12 | 0.0610 ± 0.0028 | 0.0366 ± 0.0030 |
Female TiO2 exposed | Ms6-hm | 192 | 10 | 4 | 0.0521 ± 0.0004 | 0.0208 ± 0.0002 |
Female TiO2 exposed | Hm-2 | 192 | 8 | 7 | 0.0417 ± 0.0004 | 0.0365 ± 0.0003 |
Female TiO 2 exposed | Total | 192 | 18 | 11 | 0.0469 ± 0.0107 (P = 0.84) | 0.0286 ± 0.0133 (P = 0.79) |