Figure 1

Effects of pre-adminstration of SWCNT on the replication and dissemination of T. gondii. A. Photonic emissions were assessed by bioluminescence imaging (BLI) on day 0 and 7 after parasite inoculation of mice with two different doses (10³ and 10⁴). The colour scale indicates photon emission (photons/s/cm²/sr) from T. gondii biomass over a 300 s exposure. Data are representative of mice from day 0 and 7 post-infection from two independent experiments. B. Total photon emission analysis from individual mice from day 2–7 post-inoculation, shows a strong increase in parasite burden after day 4, but non-siginificant differences between T. gondii only or SWCNT + T. gondii (ns, One-way ANOVA, p > 0.05). Results are shown as mean ± SEM (n = 6). C. Photon emission analysis from individual mice lung region of interest (ROI) on day 7 post-inoculation shows non-significant differences between T. gondii only or SWCNT + T. gondii groups (ns, One-way ANOVA, p > 0.05). Results are shown as mean ± SEM (n = 6). D. Parasite load in lungs and spleen day 7 after T. gondii inoculation quantified by plaquing assays as indicated under Materials and Methods. Non-significant differences were observed between T. gondii only or SWCNT + T. gondii (ns, one-way ANOVA, p > 0.05). Results are shown as mean ± SEM (n=6).