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Table 3 Biochemical parameters of treated mice (Mean ± S.D., n = 10).

From: Acute toxicity study of tilmicosin-loaded hydrogenated castor oil-solid lipid nanoparticles

Parameters

Saline

Til-HCO-SLN

Blank HCO-SLN

Tilmicosin (n = 5)

AST (U/L)

H

147.78 ± 37.78

157.20 ± 34.95

150.20 ± 24.15

 
 

L

152.14 ± 18.77

143.29 ± 19.79

150.00 ± 16.12

171.00 ± 17.15

ALT (U/L)

H

44.56 ± 17.37

37.11 ± 9.18

41.00 ± 10.79

 
 

L

42.86 ± 8.28

47.14 ± 11.05

49.57 ± 7.28

50.75 ± 0.96

ALT/AST

H

0.30 ± 0.04

0.26 ± 0.06

0.27 ± 0.05

 
 

L

0.29 ± 0.06

0.33 ± 0.07

0.33 ± 0.05

0.30 ± 0.03

ALP (U/L)

H

136.44 ± 34.46

150.60 ± 19.57

140.29 ± 21.47

 
 

L

121.71 ± 22.89

111.14 ± 19.30

121.50 ± 27.77

135.25 ± 17.00

TBIL (umol/L)

H

2.56 ± 1.43

1.86 ± 0.94

1.81 ± 0.89

 
 

L

0.90 ± 0.42

0.74 ± 0.35

1.09 ± 0.41

1.38 ± 1.05

CHOL (mmol/L)

H

3.86 ± 0.48

4.21 ± 0.89

3.81 ± 0.92

 
 

L

3.53 ± 0.54

3.54 ± 0.62

3.69 ± 0.74

3.67 ± 0.44

CREA (umol/L)

H

11.60 ± 3.27

13.13 ± 1.73

11.80 ± 2.53

 
 

L

18.29 ± 4.57

18.00 ± 3.42

18.25 ± 1.91

17.25 ± 0.96

BUN (mmol/L)

H

7.53 ± 1.96

7.00 ± 1.12

6.72 ± 1.11

 
 

L

8.59 ± 1.54

9.54 ± 1.48

9.47 ± 1.79

9.70 ± 0.58

TP (g/L)

H

60.90 ± 2.77

60.80 ± 2.57

56.00 ± 3.02b

 
 

L

61.31 ± 3.57

59.37 ± 1.86

60.69 ± 2.81

61.03 ± 2.16

ALB (g/L)

H

41.49 ± 1.60

40.44 ± 2.13

38.34 ± 1.26b

 
 

L

38.09 ± 4.89

37.06 ± 5.21

36.56 ± 3.35

38.90 ± 4.22

GLB (g/L)

H

19.41 ± 1.45

20.36 ± 1.31

17.66 ± 2.01b

 
 

L

23.21 ± 2.18

22.31 ± 3.94

24.13 ± 2.70

22.13 ± 2.81

ALB/GLB

H

2.14 ± 0.12

1.99 ± 0.16a

2.19 ± 0.19

 
 

L

1.71 ± 0.34

1.84 ± 0.46

1.74 ± 0.31

1.80 ± 0.41

GLU (mmol/L)

H

6.07 ± 1.68

5.98 ± 1.27

6.33 ± 1.45

 
 

L

5.18 ± 1.78

5.02 ± 1.51

4.95 ± 1.18

5.78 ± 0.57

  1. a Significant difference between Til-HCO-SLN and saline treated mice, p < 0.05.
  2. b Significant difference between blank HCO-SLN and saline treated mice, p < 0.05.
  3. Abbreviations: H: high dose; L: low dose; AST: aspartate aminotransferase; ALT: serum alanine aminotransferas; ALP: alkaline phosphatase; TBIL: total bilirubin; CHOL: cholesterol esters; CREA: creatinine; BUN: blood urea nitrogen; TP: total proteins; ALB: albumin; GLB: globulin; GLU: glucose.