Skip to main content

Table 2 Coefficients of heart, liver, spleen, lung and kidneys (Mean ± S.D., n = 10).

From: Acute toxicity study of tilmicosin-loaded hydrogenated castor oil-solid lipid nanoparticles

Compound

Heart

Liver

Spleen

Lung

Kidneys

Saline

H

0.602 ± 0.134

4.536 ± 0.632

0.333 ± 0.063

0.657 ± 0.105

1.333 ± 0.134

 

L

0.594 ± 0.051

5.038 ± 0.534

0.368 ± 0.075

0.720 ± 0.121

1.689 ± 0.271

Blank HCO-SLN

H

0.583 ± 0.070

5.063 ± 0.453b

0.447 ± 0.124b

0.626 ± 0.109

1.364 ± 0.214

 

L

0.642 ± 0.067

4.787 ± 0.813

0.426 ± 0.045

0.732 ± 0.161

1.661 ± 0.420

Til-HCO-SLN

H

0.477 ± 0.076a

5.072 ± 0.493a

0.425 ± 0.100a

0.629 ± 0.147

1.305 ± 0.226

 

L

0.618 ± 0.076

4.405 ± 0.877

0.395 ± 0.075

0.732 ± 0.119

1.659 ± 0.222

Native Tilmicosin

L

0.662 ± 0.030

4.740 ± 0.600

0.359 ± 0.076

0.707 ± 0.078

1.548 ± 0.192

  1. a Significant difference between Til-HCO-SLN and saline treated mice, p < 0.05.
  2. b Significant difference between blank HCO-SLN and saline treated mice, p < 0.05.
  3. H: high dose; L: low dose.