From: Effects of copper nanoparticle exposure on host defense in a murine pulmonary infection model
Physicochemical property | Value |
---|---|
Primary particle size (TEM) | 12 ± 1 nm |
Crystalline phases (XRD) | Cu, Cu2O, CuO* |
Surface functionality (XPS) | O, O-H and H2O |
Surface area (BET) | 12 ± 0.2 m2/g |
Pulmonary bacterial clearance study | |
Sub-acute inhalation (NP aerosol concentration) | 3.5 ± 0.4 mg/m3; 4 hr/d, 5 d/wk, 2 wk |
Aerosol size distribution** | 200 nm (1.4) |
Acute instillation (NP exposure concentration) | 3, 35 and 100 μg/mouse; 24 hr post-exposure |
Bacterial infection concentration | 1.4 ± 0.1 × 105 CFUs/mouse |
Necropsy post-infection of bacteria | 24 hr |