Figure 1

Bronchoalveolar lavage (BAL) cell differentials. BAL cells of female (A.-D.) and male (E.-H) PPARγ wild-type (wt/wt) (white bars) and PPARγ mutant mice (P465L/wt) (grey bars). Untreated home cage controls (HCC); water-instilled animals at 24 h time point (SHAM-24 h); particle-instilled mice at 24 h (CNP-24 h) and 72 h time point (CNP-72 h). For sample size, please see Table1. Statistics: General Linear Model (GLM): BAL Cell Number: genotype: F/W = 11.045, df = 1,**P = 0.001; treatment: F/W = 12.254, df = 3, ***P < 0.001; sex: ***P < 0.001; treatment × sex: F/W = 6.449, df = 3, ***P < 0.001; BAL Macrophages: genotype: F/W = 29.434, df = 1, ***P < 0.001; treatment: F/W = 9.767, df = 3, ***P < 0.001; sex: F/W = 14.869, df = 1, ***P < 0.001; treatment × sex: F/W = 4.697, df = 3, **P = 0.0039; BAL Neutrophils: genotype: F/W = 7.274, df = 1, **P = 0.008; treatment: F/W = 103.631, df = 3, ***P < 0.001; sex: F/W = 0.892, df = 1, P = 0.347; BAL Lymphocytes: genotype: F/W = 0.352, df = 1, P = 0.5543; treatment: F/W = 17.437, df = 3, ***P < 0.001; sex: F/W = 0.059, df = 1, P = 0.810; treatment × sex: F/W = 2.944, *P = 0.036;