Skip to main content
Figure 7 | Particle and Fibre Toxicology

Figure 7

From: Ultrafine particles from diesel vehicle emissions at different driving cycles induce differential vascular pro-inflammatory responses: Implication of chemical components and NF-κB signaling

Figure 7

NF-κB inhibitor CAY10512 blocked the pro-inflammatory effects of UFP2. HAEC were pretreated with 2 μg/ml of NF-κB inhibitor CAY10512 for 1 hour followed by co-treatment with 50 μg/ml (5.2 μg/cm2) of UFP2 and CAY50512 for 4 hours (gene expression) or 5 hours (monocyte binding). The expression of inflammatory gene IL-8 (A), MCP-1 (B), and VCAM (C) was measured by qRT-PCR. Monocyte binding to HAEC was measured with fluorescence-labeled THP-1 (D). (C = control; * n = 3, P < 0.05; ** n = 3, P < 0.02)

Back to article page

Particle and Fibre Toxicology

ISSN: 1743-8977

Contact us