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Figure 9 | Particle and Fibre Toxicology

Figure 9

From: Diesel exhaust particles induce CYP1A1 and pro-inflammatory responses via differential pathways in human bronchial epithelial cells

Figure 9

Proposed model for DEP-induced expression of IL-8, COX-2 and CYP1A1, based on the presented findings. DEP-induced mRNA expression of CYP1A1 in BEAS-2B cells occurs at much lower DEP-concentrations than the concentrations necessary to induce mRNA expression of IL-8 and COX-2. Activation of AhR and expression of CYP1A1 mRNA seem essential in facilitating the DEP-induced expression of IL-8 and COX-2 mRNA via a permissive pathway (required, but not decisive for the strength of the response), not involving p38 and NF-κB/p-65. However, the p38 and p65 pathways seem crucial in DEP-induced expression of COX-2 and IL-8 mRNA, via a major pathway.

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