From: Pulmonary exposure to carbon black nanoparticles and vascular effects
Exposure to carbon black | EC50 (nM) | Emax (%) | ||||
---|---|---|---|---|---|---|
ACh | SNP | PE | ACh | SNP | PE | |
2 hours | ||||||
0.0 mg/kg | 55.7 (24.5-127.1) | 17.5 (14.4-21.2) | 31.6 (24.7-40.3) | 53.4 (43.9-62.9) | 90.4 (87.5-93.3) | 67.8 (64.3-71.3) |
0.9 mg/kg | 41.6 (22.0-78.7) | 12.8 (10.0-16.4) | 21.4 (18.2-25.2) | 68.7 (60.2-77.2) | 91.4 (87.7-95.0) | 70.0 (67.6-72.4) |
24 hours | ||||||
0.0 mg/kg | 52.5 (33.5-82.3) | 11.1 (8.0-15.5) | 8.9 (7.6-10.4) | 60.5 (55.1-65.9) | 89.2 (84.9-93.5) | 73.1 (71.0-75.2) |
0.05 mg/kg | 37.1 (20.9-65.8) | 7.7 (5.7-10.3) | 5.5 (4.3-7.0)* | 53.6 (47.7-59.5) | 93.9 (90.1-97.6) | 73.4 (70.2-76.6) |
0.5 mg/kg | 59.0 (37.3-93.4) | 16.8 (13.1-21.4) | 5.8 (5.2-6.5)* | 58.2 (52.5-63.8) | 89.5 (85.9-93.0) | 72.0 (70.3-73.7) |
0.9 mg/kg | 71.3 (47.8-106.1) | 15.7 (10.5-23.7) | 13.8 (9.8-19.5) | 57.8 (52.6-63.0) | 81.9 (76.5-87.3) | 69.2 (64.6-73.8) |
2.7 mg/kg | 68.4 (33.2-141.0) | 15.1 (7.4-30.5) | 13.1 (8.7-19.8) | 52.2 (44.1-60.3) | 83.9 (75.0-92.9) | 70.4 (65.2-75.7) |
24 + 2 hours | ||||||
2 × 0.0 mg/kg | 57.4 (31.9-103.1) | 12.6 (8.5-18.8) | 13.6 (11.2-16.5) | 63.9 (55.5-72.3) | 90.1 (84.7-95.5) | 75.9 (72.8-78.9) |
2 × 0.5 mg/kg | 65.8 (42.3-102.4) | 14.3 (11.5-17.7) | 17.0 (14.3-20.3) | 41.3 (37.0-45.5)* | 91.9 (88.8-95.1) | 75.1 (72.4-77.8) |