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Figure 6 | Particle and Fibre Toxicology

Figure 6

From: Cardiovascular and inflammatory effects of intratracheally instilled ambient dust from Augsburg, Germany, in spontaneously hypertensive rats (SHRs)

Figure 6

Response of the systemic Inflammatory marker C-reactive protein (CRP) in the serum (3a), and of osteopontin (3b) and macrophage inflammatory protein 2/MIP-2 (3c) in the heart following intratracheal instillation of sham and Augsburg particulate matter (PM 2.5 -AB, exposed) in spontaneously hypertensive rats (SHRs). Bars represent arithmetic mean values ± SE of sham (n = 6) and exposure groups (n = 6). A delayed increase of CRP was observed in a dose-dependent manner whereas osteopontin and MIP2 were induced only at the highest dose. *: Significantly (p < 0.05) higher than sham, 250 μg and 500 μg exposed at day 1. **: Significantly (p < 0.05) higher than sham and exposed at day 1. ‡: Significantly (p < 0.05) higher than sham and exposed at day 1 and 3. †: Significantly (p < 0.05) higher than 500 μg exposed at day 1. ††: Significantly (p < 0.05) higher than sham and 500 μg exposed at both day 1and 3.

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