Table 3 Expression (mRNA) of Mip-2, Mcp-1 and Il-6 in lung tissue and cell distribution, DNA damage by the comet assay and protein in BAL fluid 3 and 24 h after instillation of Au and carbonaceous nanoparticles in ApoE-/- mice.

3 h

lung tissue

Mip-2

10.2 ± 3.2

34.0 ± 17.1*

10.9 ± 2.0

1170.9 ± 530.1***

108.1 ± 15.1***

SWCNT ≈ CB>Au>C₆₀

Mcp-1

10.1 ± 1.2

20.4 ± 3.4***

20.4 ± 2.1***

526.7 ± 214.8***

265.5 ± 163.9***

SWCNT ≈ CB>>>C₆₀ ≈ Au

Il-6

2.1 ± 0.4

2.7 ± 0.7

1.7 ± 0.2

411.5 ± 180.6***

31.4 ± 4.8***

SWCNT>>>CB>>>Au ≈ C₆₀

BAL

Neutrophils % ^a

3.7 ± 1.2

5.5 ± 2.6

2.8 ± 0.7

19.1 ± 8.9

13.8 ± 10.9

SWCNT ≈ CB ≈ Au ≈ C₆₀

Macrophages % ^a

93.9 ± 2.0

93.8 ± 2.5

96.9 ± 0.7

78.8 ± 9.0

83.1 ± 10.7

SWCNT ≈ CB ≈ Au ≈ C₆₀

Total BAL cells

83262 ± 4819

65081 ± 8276

68929 ± 3849

55426 ± 16930

49417 ± 7700

Comet %T

9.6 ± 0.6

11.6 ± 0.9

12.1 ± 0.9

13.4 ± 1.3**

14.4 ± 1.6**

CB ≈ SWCNT>>C₆₀ ≈ Au

Protein μg/ml

102.5 ± 5.2

105.2 ± 6.2

77.4 ± 2.9**

171.8 ± 22.2***

139.3 ± 17.3**

SWCNT ≈ CB>Au>>C₆₀

24 h

lung tissue

Mip-2

5.1 ± 0.5

8.3 ± 1.7

31.0 ± 12.8***

34.4 ± 9.0***

134.8 ± 33.2***

CB>SWCNT ≈ C₆₀>>Au

Mcp-1

28.3 ± 2.7

34.6 ± 8.5

116.0 ± 22.8***

372.7 ± 110.2***

1087.0 ± 310.6***

CB ≈ SWCNT>>C₆₀>>>Au

Il-6

1.1 ± 0.1

2.0 ± 0.5

5.6 ± 1.1***

32.5 ± 9.9***

44.0 ± 13.0***

CB ≈ SWCNT>>C₆₀>>Au

BAL

Neutrophils % ^a

5.3 ± 1.6

4.2 ± 3.1

6.4 ± 4.2

64.7 ± 7.1***

75.8 ± 3.4***

CB ≈ SWCNT>>>C₆₀ ≈ Au

Macrophages % ^a

93.6 ± 1.5

94.7 ± 3.6

93.1 ± 4.2

28.6 ± 4.9***

22.1 ± 3.7***

CB ≈ SWCNT>>>C₆₀ ≈ Au

Total BAL cells

65290 ± 5246

67881 ± 6667

76008 ± 7420

61643 ± 19999

78596 ± 21414

Protein μg/ml

110.6 ± 5.7

109.5 ± 5.2

83.6 ± 7.8***

288.8 ± 21.3***

182.4 ± 7.1***

SWCNT>>>CB>>>Au>>>C₆₀