Figure 2
A comparison of inflammation elicited in animals receiving various mass doses of UFTiO 2 and FTiO 2 suspended in BALF. A comparison of inflammation elicited in animals receiving various mass doses of UFTiO2 and FTiO2 suspended in BALF at 1 day (Panel A), 7 days (Panel B), and 42 days (Panel C) post-exposure. Rats were exposed to various mass doses of UFTiO2 and FTiO2 by intratracheal instillation. Animals were euthanized at 1 day, 7 days, and 42 days post-exposure and bronchoalveolar lavage was performed. Inflammation was assessed by BAL PMN counts. Values are increased PMN number above the BALF control and are given as means ± SE of 8 experiments. Control PMN values were 1.37 ± 0.098 × 106, 0.78 ± 0.074 × 106, and 0.88 ± 0.095 × 106 cells/rat for 1, 7 and 42 days, respectively. Linear regression analysis with a 95% confidence interval reveals that on a mass dose basis UFTiO2 causes significantly more inflammation than FTiO2 at all post-exposure time points. * indicates a significant increase from control (p < 0.05; ANOVA).