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Figure 4 | Particle and Fibre Toxicology

Figure 4

From: Single-Walled Carbon Nanotube (SWCNT)-induced interstitial fibrosis in the lungs of rats is associated with increased levels of PDGF mRNA and the formation of unique intercellular carbon structures that bridge alveolar macrophages In Situ

Figure 4

Bromodeoxyuridine (BrdU) immunohistochemistry showing a cell proliferative responses 21 days post-exposure in the lung alveolar region (panels A, C, E, G) and in the bronchus-associated lymphoid tissue (panels B, D, F, H). Saline vehicle containing 0.1% Pluronic F-68. (A, B). Carbon black treatment (C, D). SWCNT treatment (E, F). Vanadium pentoxide (V2O5) treatment (G, H). Solid arrows in panels C and E indicate aggregates of carbon black and SWCNT, respectively. Inset shows two macrophages joined by a carbon bridge within a nearby alveolar space. Open arrows indicate representative BrdU-positive nuclei. Original magnification for all panels, 40×.

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Particle and Fibre Toxicology

ISSN: 1743-8977

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