Skip to main content

Table 1 Physico-chemical characteristics of the TiO 2 -NP suspensions a

From: Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia

Dispersant

Water

Gastric

Intestinal

Ringer + FBS

cDMEM

Z-average (nm)b

132.0 ± 0.8

218.4 ± 2.9

> 1000

352.0 ± 0.9

320.5 ± 1.8

PdIc

0.188

0.330

> 0.5

0.298

0.290

ζ (mV)d

20.0 ± 0.6

30.6 ± 2.7

-21.3 ± 0.7

-13.2 ± 1.2

-10.8 ± 0.6

  1. aDLS measurements of a 50 μg/mL TiO2-NP suspension prepared either in water (“Water”), in the gastric phase (“Gastric” i.e. pepsin/HCl, pH2), in the intestinal phase (“Intestinal”, i.e. pepsin/HCl, pancreatin and bile extracts, pH7), in ex vivo exposure medium (“Ringer + FBS” i.e. Ringer solution, 10% (v/v) fetal bovine serum (FBS), pH7.4) or in in vitro exposure medium (cDMEM, i.e. Dulbecco Modified Medium (DMEM), 10% (v/v) FBS, pH7.4). bZ-average hydrodynamic diameter extracted by cumulant analysis of the data. cPolydispersity index (PdI) from cumulant fitting. dζ: zeta potential.