Figure 2

Time-course of silver deposition in liver tissues (A) and whole blood (B) following Ag-nps administration. Ag-nps were intraperitoneally injected at a dose of 500 mg kg^-1 for 1, 4, 7, 10 and 30 days. Liver tissues and whole blood samples were processed for ICP-MS analysis as described under Materials and Methods. Empty columns represent sham groups while filled columns represent Ag-nps treatment groups. Vertical bars indicate standard deviations of the mean. Number of experiments was 8 for each time points. ^* p < 0.05, ^** p < 0.01 vs. Sham; ^# p < 0.05, ^## p < 0.01 vs. Day 1; ^† p < 0.05, ^†† p < 0.01 vs. Day 4; ^φ p < 0.05 vs. Day 7.