Cellular uptake and localization of inhaled gold nanoparticles in lungs of mice with chronic obstructive pulmonary disease

Table 4 Characteristics of the inhaled AuNP aerosol

Parameter	Value
Aerosol concentration (p/cm³ ), continuously measured and averaged over the entire study time; subsequent averaging of data over all inhalation periods	1.28 ± 0.08 × 10⁷
Inhalation period (min), experimentally set	120
Tidal volume (cm³ ), estimated from pneumotachograph signals	0.18
Breathing frequency (1/min), experimentally set	120
Minute volume (cm³ /min), calculated from data above	21.6
Inhaled volume (L/120 min), calculated from data above	2.6
Deposition fraction, based on MPPD model	0.4
CMD of AuNP (nm)/GSD, measured continuously as described in text and averaged over all inhalation periods	21/1.6
Number of AuNP inhaled, calculated from data above	3.3 × 10¹⁰
Number of AuNP deposited in lungs, calculated from data above	1.3 × 10¹⁰

MPPD, multiple-path particle dosimetry (computational model to estimate human and rodent particle dosimetry). CMD, count median diameter; GSD, geometric standard deviation.

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