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Table 1 Relative distribution of AuNP (singlets, small or large agglomerates) in lung tissue compartments [%]

From: Cellular uptake and localization of inhaled gold nanoparticles in lungs of mice with chronic obstructive pulmonary disease

Animals*

Lining layer

Macs

Epithelium

  

Epithelial surface

Type Icells

Type II cells

Type I & Type II

Total epithelium

Tg 0 h

1.0 ± 1.4

24.0 ± 5.9

69.2 ± 4.9

6.7 ± 1.2

0.1 ± 0.2

6.8 ± 1.0

76.0 ± 5.9

Tg 24 h

1.0 ± 1.4

63.0 ± 18.9

15.5 ± 4.8

19.9 ± 12.0

1.5 ± 2.1

21.4 ± 14.2

37.0 ± 19.0

Tg All

1.0 ± 1.2

43.5 ± 25.3

42.4 ± 31.3

13.3 ± 10.4

0.8 ± 1.5

14.1 ± 11.8

56.5 ± 25.3

Wt 0 h

3.5 ± 4.9

58.3 ± 41.4

35.3 ± 32.2

2.5 ± 3.5

0.5 ± 0.7

3.0 ± 4.2

38.3 ± 36.4

Wt 24 h

4.5 ± 6.4

82.8 ± 0.2

9.5 ± 5.0

2.1 ± 1.5

0.1 ± 0.1

2.2 ± 1.6

11.7 ± 6.6

Wt All

4.0 ± 4.7

70.5 ± 27.8

22.4 ± 24.0

2.3 ± 2.2

0.3 ± 0.5

2.6 ± 2.7

25.0 ± 26.3

  1. Tg, Scnn1b-transgenic mice; Wt, wild-type mice. Macs, macrophages, Type I and Type II cells, alveolar epithelial cells. Total epithelium, all AuNP associated with the alveolar epithelium, i.e. attached to and within alveolar (type I and type II) epithelial cells.
  2. Data are presented as the mean ± SD.
  3. *, n = 2 per genotype and time point.